LATS Senior Awards

Hugo Niepomniszcze

Winner 1993


Hugo Niepomniszcze, was born in Buenos Aires, Argentina, on April 27, 1942. He graduated as MD from the University of Buenos Aires, School of Medicine in 1966 and received his PhD degree in 1975 at the same university. Since the early beginning of his medical career, while he was a medical student, demonstrated a remarkable interest in thyroid research, specifically on thyroid peroxidase (TPO). In 1964 he developed his first research work under the guidance of Dr. Noé Altschuler, showing that isoniazid e is an inhibitor of TPO. In the same year they published the first review article entirely dedicated to TPO (Rev. Argent. Endocrinol. Metab. 10:208, 1964). After obtaining the MD degree, he was awarded with a research fellowship from the Argentine Nationa l Council of Scientific and Technical Investigations (CONICET). He remained as a fellow of CONICET and the Atomic Energy Commission until 1970, when he moved to The University of Chicago as a USPHS International Postdoctoral Research Fellow (N.I.H.), work ing on Biosynthesis of Thyroid Hormones with Dr. Leslie J. DeGroot. He has successfuly completed his traineeship in Endocrinology and Thyroid Research in 1972 and returned to Buenos Aires as an established investigator of CONICET. Since 1974 he is the Head of the Thyroid Section of the Hospital de Clínicas “José de San Martín” of the University of Buenos Aires. In 1981 he has obtained the position of Chief of the Service of Endocrinology of the “Churruca-Visca” Medical Complex, and he became Adjunt Profes sor of Physiology at the School of Medicine of the University of Buenos Aires in 1986. Dr. Niepomniszcze has devoted his medical career mainly to the thyroid gland. During his more than three decades of thyroid research he spent the first part to basic and experimental investigations . The second period was shared between basic and clinical research, whereas he mostly dedicated the last decade to clinical investigations. The first paper on human thyroid peroxidase, reported in the world literature, was published by Dr. Niepomniszcze and his colleagues in 1969 (Acta endocrinol. [Kbh] 62:193, 1969). They also published the first direct evidences that TPO may be abnormal in congenital goiters due to impairment of iodine organification: a) apoenzyme-prosthetic group defect (New Engl. J. Med. 285:1394, 1971 & JCEM 34:607, 1972); b) deficient peroxidase defect (JCEM 36:347,1973). The inborn errors of thyroid hormonogenesis were the main field of his experimental research. He has performed studies in Chicago and Buenos Aires on new forms of TPO defects (Metabolism 24:57, 1975 & Acta endocrinol . [Kbh] 93:25, 1980), thyroglobulin alterations (Clin. endocrinol. [Oxford] 6:27, 1977), Pendred Syndrome (Acta endocrinol. [Kbh] 89:70, 1978), H2O2 generating abnormalities (JCEM 65:344, 1987) and iodide trapping defects (Acta endocrinol. [Kbh] 103:34, 1 983). He was working, also, on pharmacology of drugs affecting thyroid metabolism: isoniazide, PAS, amiodarone, phenylbutazone, minocycline, etc.; whereas he and his group had carried out clinical studies on endemic goiter, thyroid nodules, autoimmune th yroiditis, Graves’ disease, subclinical hypothyroidism, Plummer disease, thyroid cancer, TRH-TSH, and some interdisciplinary projects with dermatology, rheumatology, neurology, gastroenterology, osteology, psychology, diabetology, neumonology and androlog y. Some of these published papers are listed: JCEM 34:822, 1972; Acta endocrinol. [Kbh] 85:781, 1977; Acta endocrinol. [Kbh] 94:64, 1980; JCEM 61:28, 1985; Thyroidol. Clin. Exp. 5:25, 1993; Thyroid 5:283, 1995. He belongs to the Board of Directors of the Post-graduate Career of Endocrinology Specialty at the School of Medicine-University of Buenos Aires. He has authored more than 90 full published papers and is member of several scientific and medical associa tions: Latin American Thyroid Society, American Thyroid Association, Sociedad Argentina de Endocrinología y Metabolismo, Honorary Member of the Chilean Society of Endocrinology, American Association for the Advancement of Science, etc. He is International Advisory Board of the Ciba Foundation and Scientific Director and CEO of Buenos Aires Daim, Inc. At present, he is the Vicepresident of the Argentine Society of Endocrinology and Metabolism and the President Elect of the Latin American Thyroid Society. He also performed as member of International Committees for Nomenclature, Classifications and Def initions of thyroid disorders (PAHO Sc. Publ. Nos. 292 & 502; JCEM 73:1380, 1991 and Thyroid 2:235, 1992). Dr. Niepomniszcze was awarded with the following prizes: 1968: Prize "Sociedad Argentina de Endocrinología y Metabolismo" 1978: "Abbott" Prize of the Latin American Thyroid Society 1978: First Prize of Medicine of the Centenary of the University Hospital, School of Medicine, University of Buenos Aires. 1985: Prize "Allemand de Gunche" of the National Academy of Medicine of Buenos Aires. 1990: Distinguished Service Award of the Complejo Médico [PFA] "Churruca-Visca", Buenos Aires. 1993: LATS AWARD 1995: Prize to the Scientific Production of the University of Buenos Aires.