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SESSION 1 SUNDAY, MAY 23, 1999 (18:00-19:00)
MAIN AUDITORIUM
18:00 INTRODUCTORY
REMARKS
Geraldo Medeiros-Neto (São Paulo, Brazil)
18:15 Resistance to thyroid hormone: an overview
Samuel Refetoff (Chicago, USA)
19:00-22:00 GET
TOGETHER COCKTAIL-PARTY
SESSION
2 MONDAY, MAY 24, 1999 (08:00-10:00)
MAIN AUDITORIUM
TR STRUCTURE AND
FUNCTION
Chairman: J. M. Romaldini (São Paulo, Brazil)
Moderator: Leslie J. DeGroot (Chicago, USA)
08:00-08:30 X-ray
crystallography of TR and its mutants
Richard Wagner (San Francisco, USA)
08:30-09:00 Insights into TR mutants: Analysis of TR function
using a scanning surface mutational approach
Brian West (San Francisco, USA)
09:00-09:30 Polymorphic forms of coactivator in the modulation of
TR action
Yoshitaka Hayashi (Nagoya, Japan)
09:30-10:00 DISCUSSION
10:00-10:30 COFFEE BREAK - POSTER VIEWING
SESSION 3 MONDAY, MAY 24, 1999 (10:30-12:30)
MAIN AUDITORIUM
CHROMATIN STRUCTURE
AND CELLULAR DISTRIBUTION OF TR
Chairperson: Hans Graf (Curitiba, Brazil)
Moderator: Paolo Beck-Peccoz (Milan, Italy)
10:30-11:00 Chromatin
remodeling by TR
Alan Wolffe (Bethesda, USA)
11:00-11:30 Modification of chromatin structure by TR mutants
Trevor Collingwood (Bethesda, USA)
11:30-12:00 Cellular distribution of TR beta mutants by direct visualization
in living cells
Paul M. Yen (Bethesda, USA)
12:00-12:30 DISCUSSION
12:30-13:30 LUNCH AND POSTER VIEWING
SESSION
4 MONDAY, MAY 24, 1999 (13:30-15:30)
MAIN AUDITORIUM
THE MODE
OF TR ACTION
Chairperson: Valéria C.C. Guimarães (Brasília,
Brazil)
Moderator: Fredric Wondisford (Boston, USA)
13:30-14:00 Role
of ROR alpha in the thyroid hormone
regulated cerebellar development
N. Koibuchi (Boston, USA)
14:00-14:30 Aberrant cofactor interaction by mutant TRs in
RTH correlates with impaired transcriptional
regulation
Marc Gurnell (Cambridge, UK)
14:30-15:00 Cofactors and their influence on TR isoform-specific gene
regulation
Anthony Hollenberg (Boston, USA)
15:00-15:30 DISCUSSION
15:30-16:00 COFFEE BREAK
SESSION
5 MONDAY, MAY 24, 1999 (16:00-18:00)
MAIN AUDITORIUM
CARDIAC, CNS
AND THE RTH PHENOTYPE
Chairman: Antonio C. Bianco (São Paulo, Brazil)
Moderator: Paul G. Walfish (Toronto, Canada)
16:00-16:30 Cardiac
investigation in resistance to thyroid hormone
George Kahaly (Mainz, Germany)
16:30-17:00 TR and regulation of gene expression in brain
Juan Bernal (Madrid, Spain)
17:00-17:30 The role of cofactors in the TR-mediated negative
regulation of gene expression
J. Larry Jameson (Chicago, USA)
17:30-18:00 DISCUSSION
FREE EVENING
SESSION
6 TUESDAY, MAY 25, 1999 (08:00-09:40)
MAIN AUDITORIUM
RTH IN MAN
Chairman: Gisah Carvalho (Curitiba, Brazil)
Moderator: J. Larry Jameson (Chicago, USA)
08:00-08:20 Location
and properties of mutant TR in man
Paul G. Walfish (Toronto, Canada)
08:20-08:40 Differential diagnosis of inappropriate secretion
of TSH
Luca Persani (Milano, Italy)
08:40-09:00 RTH phenotype in the absence of TR genes
mutations
Joachim Pohlenz (Mainz, Germany)
09:00-09:20 RXR agonists in Man
Steven I. Sherman (Houston, USA)
09:20-09:40 DISCUSSION
09:40-10:00 COFFEE
BREAK
SESSION
7 TUESDAY, MAY 25, 1999 (10:00-12:00)
MAIN AUDITORIUM
ANIMAL MODELS
OF RTH (I)
Chairman: Salvatore Benvenga (Messina, Italy)
Moderator: Samuel Refetoff (Chicago, USA)
10:00-10:30 Cardiac
function, lipid homeostasis, thermogenesis and bone formation in mice
deficient for TH receptors
Bjorn Vennstrom (Stockholm, Sweden)
10:30-11:00 Cardiac function in TR alpha knock-out mice
Bernd Gloss (San Diego, USA)
11:00-11:30 A knock in mouse model of RTH
Sheue-yann Cheng (Bethesda, USA)
11:30-12:00 DISCUSSION
12:00-13:00 LUNCH AND POSTER VIEWING
SESSION
8 TUESDAY, MAY 25, 1999 (13:00-15:30)
MAIN AUDITORIUM
ANIMAL MODELS
OF RTH (II)
Chairman: Meyer Knobel (São Paulo, Brazil)
Moderator: V. K. Krishna Chatterjee (Cambridge, UK)
13:00-13:30 The
hypothalamic-pituitary thyroid axis in the thyroid hormone receptor
beta knock-out mice expressing in the pituitary the D 337T mutant
thyroid hormone receptor
Carmen Pazos-Moura (Rio de Janeiro, Brazil)
13:30-14:00 Analysis of the pituitary-thyroid axis in Tra 1, Tra 2,
Trb deficient mice
Douglas Forrest (New York, USA)
14:00-14:30 The pituitary thyroid axis in RXR gamma deficient mice
Bryan R. Haugen (Denver, USA)
14:30-15:00 Hypothalamic-pituitary axis in TR beta knock-out mice
Gisah Carvalho (Curitiba, Brazil)
15:00-15:30 DISCUSSION
15:30-16:00 COFFEE
BREAK
SESSION 9 TUESDAY, MAY 25, 1999 (16:00-18:30)
MAIN AUDITORIUM
ANIMAL MODELS
OF RTH (III)
Chairman: Carmen Pazos-Moura (Rio de Janeiro, Brazil)
Moderator: Paul M. Yen (Bethesda, USA)
16:00-16:20 Transgenic
mouse expressing the thyroid receptor and gene mutation
Peter Hauser (Baltimore, USA)
16:20-16:40 Transgenic expression of a dominant negative mutant TRß
in mouse thyroid
V. Krishna Chatterjee (Cambridge, UK)
16:40-17:00 TR beta and alpha knock-out mice
Frederic Flamant (Lyon, France)
17:00-17:20 Transgenic and TR beta 2 knock-out mice
Fredric Wondisford (Boston, USA)
17:20-17:40 RTH in SRC-1 knock-out mice
Roy Weiss (Chicago, USA)
17:40-18:30 DISCUSSION
WEDNESDAY, MAY 26, 1999
FLAT "POETA DRUMOND"
07:30-08:30 Breakfast
and check out
08:30-09:00 Review, discussion of policy and future location of the
next Workshop on Resistance to Thyroid Hormone
09:30 Departure for the International Airport (Guarulhos) for those
attending the VIII LATS Meeting (VASP flight 041, at 11:30)
Click on the link below
with the right button of your mouse
and select the "Save Link As" option.
Download
the Registration Form!
resistance-registration.doc, 25Kb.
Then
print the document, fill the blanks and send it by fax to:
WTE - Gerenciamento
de Eventos
Al. Campinas, 463 - 6A
01404-000 - São Paulo,SP,Brazil
Tel. (55-11) 253-7947
Fax (55-11) 284-6629
E-mail: wte@sanet.com.br
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